Journal CME 34.11: Neuropathologic Basis of Frontotemporal Dementia in Progressive Supranuclear Palsy

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Journal CME 34.11: Neuropathologic Basis of Frontotemporal Dementia in Progressive Supranuclear Palsy

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Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by neuronal loss in the extrapyramidal system with pathologic accumulation of tau in neurons and glia. The most common clinical presentation of PSP, referred to as Richardson syndrome, is that of atypical parkinsonism with vertical gaze palsy, axial rigidity, and frequent falls. Although cognitive deficits in PSP are often ascribed to subcortical dysfunction, a subset of patients has dementia with behavioral features similar to the behavioral variant of frontotemporal dementia. In this study we aimed to identify the clinical and pathological characteristics of PSP presenting with frontotemporal dementia.

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Faculty:

Nobutaka Sakae, MD, PhD

Keith A. Josephs, MD  

Irene Litvan, MD  

Melissa E. Murray, PhD  

Ranjan Duara, MD

Ryan J. Uitti, MD

Zbigniew K. Wszolek, MD

Neil R. Graff-Radford, MBBS  

Dennis W. Dickson, MD

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