Journal CME 34.07: A critique of the second concensus criteria for multiple system atrophy

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Journal CME 34.07: A critique of the second concensus criteria for multiple system atrophy

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Multiple system atrophy (MSA) is an adult-onset progressive neurodegenerative disorder that manifests clinically with autonomic failure, parkinsonism, and ataxia in any combination. Oligodendroglial cytoplasmatic inclusions consisting of misfolded α-synuclein are a pathological hallmark of disease.1 The clinical diagnosis of MSA is typically delayed as a result of incomplete or nonspecific manifestations during early disease stages.2,3

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